eGFP RNA stored in different stabilizing solutions for over 1 year at room temperature displays little degradation. Maintaining a comparable molecular weight & band sharpness to RNA stored at -80°C
RNA Stored in Stabilizing Formulations
Vs
RNA Stored in Common Buffers
Over 1 Year at Room Temperature
RNA Stored in Solution is Transcribable by RT-PCR
RNA stored in stabilizing solutions for over 1 year at room temperature can be reverse transcribed using RT-PCR to produce full-length double stranded DNA of comparable size to RNA stored at -80°C. Suggesting RNA bases remain intact and unaltered during storage in RNA stabilizing formulations.
Reverse Transcription & PCR eGFP RNA stored in solution for over 1 year at room temperature
Lipid Nanoparticle Compatible
LNPs Maintain RNA Encapsulation at Room Temperature
Stabilizing formulations improve SM-102 lipid nanoparticle stability & encapsulation consistency following storage for 30 days at room temperature compared to standard storage buffers.
Encapsulation of RNA in SM-102 LNPs Stored in Solution for 30 Days at Room Temperature
Dramatically Improved Stability
RNA Encapsulated in Lipid Nanoparticles
RNA encapsulated in SM-102 LNPs stored in stabilizing formulations maintains excellent stability compared to Tris and Sucrose alone
eGFP RNA LNPs stored in solution for over 100 days at room temperature
Extreme RNA Stability
Under Harsh Storage Conditions
Many RNA stabilizing formulations are extremely robust, capable of maintaining RNA stability under high temperatures for days or even weeks. RNA stored in stabilizing solutions maintains integrity and doesn't degrade even after 8 days at 60°C.
eGFP RNA stored in solution for 8 days at 60 degrees Celsius
